Authentic Therapeutic Telomerase Products

The Pursuit of Telomere Health Products Based on Solid Science

Guest Blog by @TelomereRX

Published elsewhere as Storify Blog

Twitter Profile
Twitter Profile

Clarity and integrity of process is paramount in the introduction of new science and its beneficial application.  Disinformation ties a yellow ribbon around every product or service tree obscuring the genuine gold for society in scientific progress.  It is easy to hashtag a label on social media and plug a product with little or no science behind it.

It is also important for us to realize, as tweeted by Margaret Atwood, that all publishing, even via easy-on social media, still bears every accountability and liability of any published work.

@TelomereRX seeks specifically to identify effective therapeutic application of Telomere Science as represented by 2009 Nobel Prize Laureates, Elizabeth Blackburn, Carol Greider and Jack Szostak as well as other leading academics and Telomere Scientists like Bill Andrews, Maria Blasco, Jerry Shay, Calvin Harley and Sandy Chang.  Leading practitioners of therapeutic application we follow include Gabriel Cousins and Ed Park.   Bill Andrews and Noel Patton belong to a category of courageous and ground breaking entrepreneurs seeking to link the best of responsible science with its earliest effective and safe therapeutic application.

The complex matter of early stage telomere testing procedures, due a separate blog, represents a nascent field of entrants where even the most advanced laboratories are challenged to replicate consistent readings from the same samples.  The lower cost less specific labs find themselves marketing a service for determining average telomere length that is increasingly marginalized by the evolving science as insignificant to individual health diagnosis because effective treatment is measured by a reduction of short telomere clusters not average length of a body’s general cellular telomere population numbering several quadrillion in the adult human.

A significant challenge for Telomere Science in realizing an application for human life extension is that it serves little purpose for government or vested interests and therefore lacks official funding.  It also threatens to revolutionize and simplify general health diagnosis and follow up care which currently thrives on complexity and its status as a valued growth industry that perpetuates itself on symptomatic treatment rather than health breakthrough.

It is the intent of writings like this to stimulate a crowdsourced dialogue to progressively distill the status of this ongoing science, also to clarify the  formulation and  science honesty of products and finally to highlight the effectiveness of services to the benefit of those seeking health and not just treatment.

This particular Twitter discussion revolves around Sisel Safe, one of the more prolific users of the twitter hastagged  #Telomere  and  #Telomerase.  There seems to more enthusiasm than scientific substance offered for this product.  We  would be pleased to have a response from the company itself or one of the 15 company scientists alluded to yesterday in a now deleted tweet.

Some background on this discussion:

1. Follow up studies on nutraceuticals that can lengthen telomeres are underway but are both time consuming and expensive.  Currently, products that contain proven telomere lengthening antigens in vitro lack the adequate scientific follow up studies for in vivo ((human) application.  They may therefore be labeled as a Telomere Support Product until reliable and consistent findings from the studies confirm encouraging anecdotal reports.

2. Among more than 16,000 peer reviewed articles on telomeres and health it is generally agreed that all healthy lifestyle choices including even moods, exercise or responsible nutrition can mitigate the progressive annual shortening of telomeres of a minimum of 50 to 100 base pairs. Therefore any healthy product can claim to be telomere supportive.

3.  The following Twitter exchange refers to the astragalus  herb ingredient which is a proven Telomerase activator at 6% HeLa, with a 100% HeLa activation being an agreed standard for full activation of cell immortality.  Specifically it is the TA-60 and 65 phytochemicals in the herb root that were identified by the University of Hong Kong as activators and not the root itself.  Noel Patton’s company states that it takes over 1000 pounds of astragalus root to harvest enough TA-65 for single person’s annual dose.  Thus the high prices.  It is possible to achieve better prices by adding only the root and not the expensive phytochemicals to a telomere support product. Sissel Safe however claims that “TS-X is the most powerful anti-aging and longevity support product ever.” at a fraction of the the TA-65 price.  That seems unlikely particularly when they seem reluctant to share the science behind their claims

4.  Bill Andrews who discovered the human telomerase gene in 1994 and provided the scientific platform for subsequent telomerase activation research, helped spearhead the initial launch and test of Noel Patton’s TA-65 in 2007.  He has since launched Product B, a nutraceutical including 15 proven telomerase activators but containing no astragalus phytochemicals. In his A4M address in December 2013 at Las Vegas he said there were three products on the market today that his laboratory has verified to activate telomerase production in the cell and stimulate telomere re-lengthening.  Since Bill already disclosed Product B and TA-65 as proven activators this article asks the question if Sissel Safe is the third proven product.

We welcome your feedback.

This Twitter record of the discussion is also available reading first tweet from the bottom and up.

Response from Dr. Ed Park to this Article

Tweet TelomereRx

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Who Wants To Live Forever

[A version of this post appears on HECMWorld.com]


 

Who Wants to Live Forever?

Guest Blog by Amara Rose 

Follow Amara’s writings at LiveYourLight.com

and on Twitter @Amara_Rose 


 

In the landmark film, The Graduate, there is a memorable scene in which an older businessman intercepts a young Dustin Hoffman, intent on giving him sage advice. He leans in and says confidentially, “Young man, I want to say one word to you.  Plastics.”

If the film were being made today, that businessman might whisper, “Telomeres.”

These protective end caps on our chromosomes determine how quickly we age and die.  Each time our cells divide, the telomeres shorten. Shortening telomeres equal a shortening life.

However, in 1984 scientists discovered a game-changing enzyme, telomerase, that slows, stops, and can even reverse telomere shortening.  We’re born with the telomerase gene “turned off,” making natural aging inevitable.  But if (when) we find a way to switch this gene on, we will have the ability to become immortal. Such research is already underway.

Which is a bit scary.  What, for instance, would living forever (or at least for several centuries) mean in terms of work, retirement, finances, and, dare I say it, potential boredom? Not to mention planetary carrying capacity.

I’ve just read Dan Brown’s latest, Inferno, in which a genius geneticist concocts a plague that will wipe out a third of Earth’s population, his intent being a variation on the theme, “destroy the world in order to save it.”  And in a breathtaking earlier novel, The Eight by Katherine Neville, an elusive elixir of immortality is relentlessly pursued across continents and centuries, no matter the cost.

So living forever may not be in our best interest just yet. Spiritual maturation as a species comes first.     And, we are growing there.  In the meantime, the Boomer generation is reinventing the concept of how and when to die. Just as they reinvented retirement from a time of withdrawal and relaxation to one of encore careers, they are reclaiming death from fear, pain, and suffering to a time of dignity and control.   Clearly, Boomers do not intend to “go gentle into that good night.”

With the last taboo now a subject of dinner conversation at more than 500 Death Cafés worldwide, it seems safe to say that unless and until telomerase is on tap in every home, Boomers will want to discuss and determine what their end of life will look like.  So if you work with the “chronologically gifted” or are among this cohort group yourself, ostrich syndrome is no longer an option.

This evolving demographic wants meaning, purpose and closure as their lives ripen and they embrace the power and potential time and wisdom confer.  Boomers know it’s a stunning moment to be aboard Earth, in control of one’s destiny.  And their telomeres are driving the train.

 

About the Author: Amara Rose is a metaphysical “midwife” for our global rebirth. She offers personal and business alchemy for individuals and organizations, including coaching, content development, branding, social media and strategic marketing. Learn more at LiveYourLight.com, where you can subscribe to her inspirational e-newsletter, What Shines.

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An Open Mind On Turning Back the Aging Hands of Time: Are We Ready for a New Wellness Paradigm (Part 1)

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My Swedish uncle used to say that it is better to be young, healthy and rich rather than old sick and poor. That line always drew a chuckle because of its obvious observation and stark contrasts.  How would you respond if I told you that young, healthy and rich was within the reach of every single human alive today, that it could be possible to wake up tomorrow with the realization that you could have 30, 60, 90 or more years of vibrant wellness ahead of you instead of maybe 10 to 50 years of progressive deterioration and sickness?  In truth though, would you really want more years, even if they were available and came with vibrant health?

Before you shut me down and dismiss me as a wacko may I suggest that all it may take to slow down your aging process, to maybe bring it to a halt or even reverse it for some aspects of your body, is to open your mind that this could be possible.  The magic words are Telomeres and Telomorase.

The 2009 Nobel Prize for Medicine and Physiology was awarded for breakthrough research in Telomere Science.  Telomeres are the protective end caps on the four limbs of our DNA filled chromosomes that  keep the DNA from unraveling or fusing with other chromosomes each time the cell nucleus divides to facilitate healing or renew tissue. With each division your telomeres shorten.  As our telomeres shorten we lose our health edge.  Telomere length has become a marker for biological aging.

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The Nobel prize was about discovering an enzyme, telomerase, that slows, stops or even reverses the process of telomere shortening.  To restored telomere length is to restore youth. It was discovered that each cell has a telomerase gene or factory but that we are born with that gene switched off in all cells except our reproductive cells. Reproductive cells, however, are immortal.  The telomeres in these cells never shorten or age else our children would all be born with progressive Progeria, a rare disease of short telomeres at birth, and all human life would be extinct in two or three generations.

Progeria txt

The age reversing properties of telomerase was proven in the laboratories in 1997 with human skin cells, then mice in Spain 2007 and at Harvard 2010.

A typical gut response to the prospect of increasing longevity may be that the earth is already creaking under unsustainable over-population and it is our duty to alleviate the problem by dying sooner rather than later.  This may be flawed and uniformed thinking.  Consider that our concept of population explosion may be over-hyped and plain wrong.  For example, according to National Geographic the world’s 7 billion people can stand shoulder to shoulder within the city limits of Los Angeles.  Perhaps increased and healthy longevity for large numbers of the global population is one of the only solutions to a major crisis facing organized society today.  A larger question may be: If vital longevity is available would you want it?

History as I wrote in an earlier blog is replete with game-changing  random and blind-siding events we call Black Swans that radically change society as we know it.  A recent Forbes article calls depopulation the next Black Swan.

While there is a  baby boom  underway in Sub-Sahara Africa where the average woman is having 5 babies, much of the rest of the world is experiencing rapidly declining birth rates and even depopulation due to increased access to technology and the distraction, demands and costs of a related modern lifestyle.

The most direct impact on birthrate could be internet access.  A Microsoft report earlier this year predicts that the current 2 billion internet users will double to 4 billion by 2020.  Citing an expected 100 times improvement in data transmission efficiency in the next 5 to 10 years Facebook’s Mark Zuckerberg  has garnered a consortium of a half dozen of the world’s tech giants, including Samsung, Nokia, Qualcomm and Ericsson that together aspire to expedite universal internet access by slashing infrastructure and device costs in hungry search of new customers.

Internet Users 2020

History shows that when people go on line they are more interested in making friends on Facebook than making babies in the bedroom.  As people get on the net, a whole new world of information and opportunity opens up.  People move from rural to urban areas and new cost of living and lifestyle demands tend to postpone having a family. Young women no longer stay home tending to chores and domestic duties as jobs and potential careers present unprecedented opportunities and demands.  Not Africa and not any country in the world will experience expanded internet access and maintain high birthrates.

IndiaSmartphone

Apart from natural calamities, sweeping pandemics, alternate social agendae or the steady deterioration of food, air and water quality there are other challenges to a continued stable population base. Population manipulation like three decades of one child policy in China and the widespread practice of gender selection in the world’s two largest countries amounts to 400,000 million missing siblings in China and upwards of 80 million missing girls in China and India.  This will have a generational domino impact on both population and economic stability that will not be solved in a mere century.

Ninety percent of urban and sixty percent or rural families in China have a single child.  The average family in China today is a precarious upside down pyramid of  up to four grandparents and two parents balancing on a single child expected to care for and support all family elders in their growing dependency.  Despite widespread easing in the past two years of the one child restriction that now allows for a second child where both of the parents are single children, and in some areas where only one parent was a single child, there has been limited increase in births.  City life and a woman’s career is already expensive and complicated without the compounded cost and obligation of caring for one more child. Factoring in this history and these conditions the current 1.38 billion population of China is predicted to peak in 2025 at 1.44 billion and decline by the end of the century to 1 billion.

Developed countries are shrinking. Europe’s population peaked in 2000. The 34 OECD countries with the world’s leading economies that command more than 60% of the global economy with less than 18% of its population are experiencing population stagnation and even decline. Despite having youthful,  populous countries among its members like Mexico and Turkey these 34 countries combined are expecting a net population growth of only .2% by 2050. This spells serious consequences for a business model designed to feed on unrelenting and perpetual growth.

It will be a mean game facing the future with shrinking populations.  Wall Street icon Peter Peterson, peer and advisor to world leaders, in his book The Gray Dawn tells of ringing the alarm bell in his affluent circles since 1980 to warn of a looming iceberg that threatens to sink civilization as we know it today and “disenfranchise generations to come”.  He participated in the 1994 Kerrey-Danforth Commission which concluded that, absent major tax and government spending reform, “the benefit outlays for just five programs–Social Security, Medicare, Medicaid, and federal civilian and military pensions–will exceed total federal revenues by the year 2030. This would leave zero tax revenue for any other purpose–not even for interest payments, nor for national defense, nor for education, nor for child health, nor for the federal payroll. Not a penny available for anything else.”

Some may perceive Peterson as a budget deficit scaremonger seeking to loot social programs in aid of tax reform and a right wing agenda. That explanation, whatever its merits, does not make the potential mayhem of an untended gray baby boomer tidal wave go away nor does it offset the decades of neglect in preparing for an event now upon us.

In the USA the largely bankrupt federal and state governments on top of everything else face their share of a staggering national health expenditure this year of 2 ½  trillion dollars.  The federal government has allocated one quarter its current $3.8 trillion budget to bear 40% of this cost.  Stretching the old worn rubber band of perhaps the modern world’s most costly, ineffective and compromised “sickness” industry to meet the demands for health from its exploding senior demographic has little prospect of success, satisfaction or sustainability.

The current deadlock in Congress over ObamaCare seems to transcend partisan politics and may be rooted more in the public’s mistrust in their government’s ability to grasp and deliver Health along with the ostensible Care of HealthCare and a doubt that government and traditional medical practice have the tools, structure and orientation to do so.  The only thing that seems to be obvious is that structured public mega-funding will be indentured to serve an old system, in old and paternalistic ways with little hope for better or even adequate outcomes.

So leaving this cheerless scenario aside for a moment, let’s visit the opportunity once more we have before us, the getting younger, healthier and wealthier one.  If living a much longer and much healthier life was offered to you today, would you accept it?  Would you want it not to be true because it is a Black Swan that contradicts how you understand things should be.

… or do you want to know more?

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Trading Places

TODAY A TWITTER FRIEND AND ENGINEER FROM AFRICA ASKED ME  ABOUT  job prospects in North America.   http://bit.ly/19kX19A   This is my, probably unexpected, reply.

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Dear Friend,

A recent somewhat defensive study from a group advocating the continued ascendancy and privilege due to those of white European origins came to some alarming – for them – conclusions.  The study discovered that there is today exactly a 1:1 ratio of the roughly one third of the global population that is labeled black or white.  As recently as 1950 the white/black ratio was 3:1.

As a percentage of world inhabitants the white population will plummet to a single digit (9.76%) by 2060 from a high-water mark of 27.98% in 1950. Using 2010 as the base reference, the black or sub-Sahara African group will expand almost 133% to 2.7 billion by 2060. By the middle of this century blacks will represent 25.38% of world population which is up dramatically from the 8.97% they recorded in 1950.  This is almost an exact reversal of global black white population proportions within approximately a century.

THAT 1950 3:1 WHITE/BLACK RATIO WILL DRAMATICALLY TRADE PLACES IN JUST OVER A CENTURY.

Trading Places

In 1950 whites and blacks were, respectively, 27.98% and 8.97% of world population. By 2060 these figures will almost reverse as blacks surge to 25.38% and whites shrink to 9.76%.

Inside systemic global funds and their long range economic plans were allocated to Africa a decade or more ago because, more than anywhere else on earth, Africa is emerging as the most robust international market for cars, refrigerators, digital technology and other consumer goods and empowered lifestyle cravings.  Already Africa enjoys relatively advanced and more affordable cellular phone technology, while in North America, dumbed down and unnecessarily expensive smartphone technology and access  is designed to pay dues still owed on a century old financed cross-country grid of copper wiring.

You ask about job opportunities in America.  Consider this. Compared to even Europe and the rest of the world the vested interests in America are struggling to maintain their control by repressing advanced technology.  This should concern you as an engineer.  Detroit car manufacturers have sued the state of California for future emission standards that have already been in effect in China for many years. The very same car makes and models in Europe that routinely get over 50 mpg are re-engineered to a more suitable 35 mpg in the US to support the oil industry and the tax structure.  This production model Volvo hybrid, for example, that gets up to 130 miles to a gallon, and is illegal in the USA, must leave the country within 30 days if brought in as a tourist vehicle.  Failing that it is subject to being seized and dismantled.   http://jimstonefreelance.com/50plus.html.  To introduce this model and technology to the USA Volvo has scaled back the range by more  than half and is currently labeling it as a “concept car”.  

Volvo-V60_Plug-in_Hybrid_large

Mature economies like America are struggling to stay viable.  They are bearing the burden of depopulation and servicing a rapidly graying and socially top-heavy population.  Canada and the USA are notably losing a viable middle class as market forces and government policies are increasingly  impoverishing the many and benefiting the few. Today one family alone in the USA has a greater net worth than 40 % of the entire population and few families can stay above the poverty line with a single spouse in the workforce.   In North America I see a continuing trend of full time jobs being replaced by minimum wage jobs.  The weekly paycheque continues to shrink causing social unrest.

The developed world faces an international right-sizing (deflating) of historically engineered currencies and economic privilege. America’s international special halo status is tarnishing even as it only begins to contemplate a fair-minded and non-military strategy to meet its seriously over-due and crippling international debt obligations.

Well qualified professional immigrants like you coming to North America often end up driving taxis or taking other menial jobs due to industry protectionism that routinely and unreasonably denies the validity of foreign professional certification. Too often  a punishing re-certification process is invented to reduce job competition .

All by themselves the Western Developed World has fashioned the painful social and economic dilemma in which it is  enmeshed but segments of the population are only too eager to find convenient scapegoats to bear the blame.  Immigrants and even people of different colour can be most welcome suspects.

If  you still wish to leave Uganda for work then Europe is much safer. The USA incarceration rate is more than 10 x greater than Europe for essentially similar economies.  If you happen to be Black or Hispanic the rate within the USA is 5 times greater than that 10:1 ratio. As a black male in the USA you are 31 x more likely to be jailed than you would be in Uganda. If you raise a black son in the USA, time was (in 1980) that 3:1 on average he was more likely to go to college or university than jail.  Today more black young men go to jail than higher education.  In this regard Uganda is much more enlightened than America. Stay safe.  Stay Home.

The opportunities and strong future for you  are overwhelmingly in Africa not in the shrinking economy of any OECD country.

I advise you to stay home and help build the emerging new world in Africa.  Enjoy the new technologies you already have in Uganda that may not be available or legal in America. You may do well to contact a hungry North America or Europe based engineering firm to offer your professional and local expertise to help them capitalize on this arriving tidal wave of construction and development that is materializing faster than you could possibly believe.

I suggest you experience the US and Canada as a tourist rather than immigrant.  They are wonderful countries to visit but daunting for an immigrant mainly because they are in economic decline.

Africa today offers unprecedented growth and development opportunities for Africans and for the rest of the world.  Being a bridge to that opportunity could be a very good choice for you.

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Bill Andrews – Telomere Scientist and Therapeutic Telomerase Pioneer

Bill AndrewsMyBlog1

ChromosomeTelomereBlog

BILL ANDREWS HAS AN IDENTICAL TWIN BROTHER THAT THE FAMILY SAYS     is more and more noticeably an older man standing beside his youthful and, at 61, athletically evolving brother, Bill.  A clip from an HBO film in progress, for release in Q1 of 2014, shows Bill at 60 years old running a 138 mile non-stop ultra-marathon race last summer in the Himalayas cresting 18,000 feet. He finished 5th in a field of much younger runners where finishing the race itself was a rare accomplishment.

What is interesting is that Bill’s times and stamina keep improving. He is now constantly breaking his previous records and is targeting running the mile in 7 minutes … at 130 years old. Last year at age 60 he broke 7 life time records.

Bill Andrews, Ph. D., is a 32 year veteran Medical/Pharmaceutical Biologist and renowned Geneticist, named on 45 U.S. medical patents in the field of telomere research. He has already been in this field 20 years and some industry insiders feel he has a 10 year jump on the nearest industry activity as no one else is yet pursuing the kind of research he is doing, seeking to directly unlock the activation secrets of this process of continued cellular renewal.

Popular Science featured Bill Andrews and his work in a six page article in its Aug. 2, 2011 issue, that appeared on the news stands just days before Bill introduced a nutraceutical telomere supportive product called Product B™.

A similar nutraceutical product, TA-65, has been on the market since 2005.  Although it is weaker per unit activation strength it nevertheless has met with a sensational and extensively documented response. Bill Andrews had a part in this product’s origins, was a prime candidate for a one year initial test and co-authored follow up scientific studies, the latest of which was released at the end 2013.

In 2009 the Nobel Medical Research prize was awarded for telomere research because of the momentum and visibility this field had gained over the previous three decades and witness to the growing buzz of its promise of potential age reversal. 

Elizabeth Blackburn and her assistant Carol Geider on Christmas day, 1984, working with a single cell pond scum organism, the tetrahymena, discovered telomerase, an enzyme that lengthens the telomeres and activates cell immortality.  The race was then on to find a human telomerase gene and to identify a way to activate its production.

Hearing of this for the first time in 1993 at a conference where Calvin Harley of Geron Corporation was the speaker Bill was mesmerized by the possibility of conquering aging, a goal he committed to at age 8 and recommitted himself at 12 years old. He says that all through high school and college he was known as the person who intended to conquer aging.  He asked Harley to hire him and promised he would find the human telomerase gene within three months.  “Geron believed me.  They must have been aware of my reputation of being involved in a lot of big biotech discoveries.”, Bill says, referring to his ten years as a serious pharmaceutical biologist having assisted in the discovery of Human Growth Horomone and  EPO (Erithropoietin) – both later to evolve in sports enhancing drugs –  as well as  Tissue Plasminogen Activator an anti- clotting agent for coronary emergencies that has today become a standard issue for every ambulance.

Bill started with Geron within two weeks. Three months and seventeen days later the team Bill led successfully cloned the human telomerase gene.  Shortly after, his team also identified the protein components of that gene.  This provided the context to discover what protein suppressant was turning off the telomerase production in the cells causing aging and to find a way to activate telomerase in the cell by canceling the suppressant.

This discovery spurred an explosion of scientific papers exploring the relation of disease to length of telomeres.  Published articles on telomeres rose from a handful up to that point to more than 16,000 today.

Pub5

http://www.lifelength.com/pdf/Life_Length-Presentation_for_AMWC_2013-Moscow.pdf

After five years with Geron as Director of Molecular Biology, to Bill’s disappointment, his financially strapped employer veered towards a more bank friendly strategy of finding a telomere cancer drug application.

Bill was committed to aggressively pursue the most direct link to the anti-aging state of lengthened telomeres which was a dedicated search for teleomerase activator compounds. Reluctantly he left Geron to maintain his priorities and set up his own company, Sierra Sciences in Reno, Nevada.  Bill chose Reno because it was a city that ran 24/7 allowing him to do research around the clock.  He located across the street from Reno/Tahoe International airport so they could have instant global connections.

At least five prominent telomere scientists were skeptical that Bill would ever find a chemical to activate the latent telomerase gene present in every cell.  Upon finding a cellular spike in telomorase on his 57,684th try Bill sent the activator compound to his doubting peers, each of whom confirmed his discovery.  After that Bill would quote their findings as confirmation of his discovery.

Bill set out to produce within 15 years an FDA approved pharmaceutical drug that activated the telomerase gene testing hundreds of thousands of chemicals to that end. As a Pharmaceutical researcher he knew this would be a costly and lengthy venture.

According to a Forbes article studies show that from 1997 to 2011 the average new drug cost $5.6 billion to produce over ten years.

The 2008 economic crash seriously affected Bill’s investors, Logitech co-founder Pierluigi Zappacosta and Richard Offerdahl, co-founder of  Zycad Corporation and majority owner of Digi International during it’s boom days.  Funding was seriously curtailed causing staff and research at Sierra Sciences to be greatly reduced.  By fortuitous chance Bill was introduced in April 2010 to master product formulator John Anderson, from Chandler, Arizona who had developed 2300+ natural ingredient health products in 27 countries for more than 600 companies, including the US government.

John Anderson, with years of experience traveling around the globe researching diets of long life communities gained a new urgency after being bitten by a brown recluse spider in 1999 that blinded him in one eye and seriously compromised his immune system. Battling for his life he stepped up his efforts to find, formulate and prepare botanicals, natural bacteria and other material to overcome his own health challenge to restore his eyesight and immune system.

Successfully regaining his health through natural treatment and new discoveries he went on to co-found Isagenix in 2002,  with health industry veterans Jim and Kathy Coover, to  distribute his health products on a peer to peer sales structure.   Isagenix has generated more than $2 billion in total sales of John’s products with current annual sales of $300+ million targeting $500 million for fiscal 2013-14.

In their initial conversation John suggested that Bill could bypass the prohibitive FDA cost/delay and regulation of a drug rollout by creating a nutraceutical formulation sourcing chemical compounds from natural botanicals of Chinese, Ayurvedic and European origin.  These botanical ingredients are labeled by the FDA as GRAS – generally regarded as safe.

Bill by the time he met John Anderson had tested 304,000 chemical compounds to find 300 partial activators to turn on cellular Telomerase.  (A number that currently exceeds 500,000.)  Unfortunately, while these compounds lengthened the telomeres of human cells in a petri dish, the cells routinely perished after 5 to 6 days due to the toxic nature of these chemicals.  He had also tested  2600 friendlier natural compounds without a single hit leaving him skeptical of their future potential as activators.

In September 2010 John sent Bill an initial shipment of 15 possible activators which incredibly included one ingredient giving a positive hit as a telomerase activator. This was repeated in the next shipment of 15 botanicals.  By the summer of 2012 a third generation Product B was formulated that exceeded the base level Bill had previously reached, notably without the toxicity levels that killed the cells and impeded human formulation.  What shocked Bill was that several of the ensuing botanical preparation products he would receive from John were the same natural products he had tested without success.

John, personally, in his company, Dream Master, LLC,  secured exclusive distribution rights for all nutraceutical (natural) telomere activation products produced by Sierra Science and  built a $4 million state of the art 5 person lab in his backyard to prepare and test samples for Bill’s research.

Currently one can get the average length of their telomeres tested in various labs for about $200 – 300.00.  This is only marginally helpful as each person’s health is vulnerable to their shortest telomeres and telomerase introduced into the body goes to work on these clusters of shortest telomeres first. While only the Life Length™ testing system at about $700.00 per test is able to identify this activity Bill says he has designed, in concept, a new testing process that he aims to implement once adequate funding is available.

Bill has had a good collaborative relationship with Dr. Maria Blasco.  Dr. Blasco is the Director of the Spanish National Cancer Research Center in Madrid where she leads a staff including more than 200 medical doctors and Ph D’s.  She is a prolific researcher and publisher of more than 130 scientific articles on the life extending nature of telomeres and is the founder in September 2010 of Life Length , a company with the objective of commercializing her system of Telomere Analysis Technology (TAT).  Life Length™ is regarded as having the most accurate comprehensive telomere length testing available. In clinical studies underway Dr. Blasco is working with Dr. Andrews to measure change in telomere length of subjects taking Product B™.

While Bill and his team at Sierra Science were able to demonstrate telomere lengthening of human cells in a petri dish and elimination of cellular cancer by introducing telomerase, his peers and associates made startling progress in experiments with rats and telomerase. A team led by Maria Blasco, in Spain in 2007, was able to significantly increase the lifespan of rats with a single dose of telomerase.

Subsequently, researchers at Harvard, in 2010, dramatically  reversed the aging of old mice. Mice with an equivalent human age of 80-90, with deteriorating skin and shrunken brains, unable to reproduce and find food in a maze, were within a single month transformed by the addition of telomerase to young vibrant rats with entirely restored brain size and reproductive capacity.  “It was everything we could have hoped for.” said lead Harvard researcher, Ron Dephino.   The media including Diane Sawyer of ABC News reported widely on this.  

Two years after receiving John’s first samples for testing and just one year after the launch of Product B on August  14, 2011, Isagenix introduced a 3rd generation stronger formulation for Product B™.  Bill Andrews was astounded that this formulation in two short years, using only natural products, rivaled the base activation strength of the strongest but “too toxic” chemical activator he had discovered over the previous decade plus of concentrated research prior to meeting John Anderson.

Research and development of further activators continues to provide for a progressively improved and strengthened Product B™.  Bill Andrews speaking August 2012 said he and John Anderson to date have collaborated to find 15-20 natural botanical activators one of which, in itself, actually exceeds the strength of the strongest chemical activator his company had ever previously discovered.

The single event that may have influenced the Swedish Nobel Committee on Physiology or Medicine to select Telomere Research for its annual prize may have been the introduction of TA-65 in 2007. In 2002 industrialist and investor in Geron Corporation, Noel Patton, licensed a proven single ingredient telomerase activator from the financially challenged company to produce and market an anti-aging nutraceutical pill that supported and lengthened telomeres.

The product was introduced to the market through medical doctors. In 2007, Patton signed up about 100 affluent subjects who were willing to pay $25,000 each for the privilege of taking his untested supplement for a year while having their health closely monitored.

The chemical compound at the heart of the supplement, isolated and intensively refined from the traditional  Chinese herb astragalus, was the only natural and non-toxic substance that had ever been discovered to enhance, albeit modestly, the body’s ability to produce the enzyme  telomerase.

Bill Andrews was the first one to sign up and experienced a significant boost in his health and ultra-marathon performance while taking this capsule. Many of the other subjects reported big lifts as well, cognitive, sexual, all-around vitality etc. The athletes who subsequently signed up seemed particularly enthusiastic about their personal performance improvement. Dr. Joseph Raffaele, a prominent New York anti-aging doctor, Calvin Harley, the Telomere specialist at Geron who hired Bill Andrews in 1992, Maria Blasco, head of the Spanish National Cancer Research Center, and Bill Andrews, co-authored a paper detailing the findings of the yearlong study. Among other observations they found that TA-65 did not increase the mean length of telomeres but in almost every case reduced the number of short telomeres. Bill reports the unexpectedly positive results of the study.  

“After TA-65 had been available for public consumption for approximately 3½ years, Sierra Sciences, TA Sciences, Geron Corporation, PhysioAge, and the CNIO jointly released a publication on its effects in September 2010.  They found that patients taking TA-65 had proportionally fewer immune cells with critically short telomeres than they did at the beginning of the study. In individuals infected with CMV,  a virus which prematurely ages the immune system and significantly reduces life expectancy, there was an even more dramatic improvement of the immune system that represented an apparent “age reversal” effect of approximately 5 to 20 years based on one biomarker of  immune aging.”

The news media, celebrity anti-aging icon Suzanne Sommers and several anti-aging doctors enthusiastically endorsed the product.

Though Astragalus is a relatively weak telomerase activator  impressive results continue to be realized through this product, in part due to its concentration (a years TA-65 supply for one person is extracted from about 1000 lbs of astragalus root ).  Dr. Ed Park an Orange County, California Medical Doctor trained at Harvard and Columbia Universities was the 19th person to sign up for the intial TA-65  study in 2007 and continues to report impressive results personally and for his patients.  He is recognized as a leading anti-aging medical doctor.    

Today Bill’s own telomerase activator/supportive capsules are on the market containing numerous bundled activators.  TA Sciences states upwards to 20,000 people have taken TA-65 over six years with no adverse effects. Isagenix says several hundred thousand people are currently taking Dr. Andrews’ and John Anderson’s collaborative formulation, Product B™.

TA-65 is available through doctors specially licensed with TA Sciences.  Product B™ is available through peer to peer Isagenix distributors.  While there are numerous copy cat products on the market claiming fountain of youth benefits Bill Andrews says his lab has tested them using the PCR process.  They routinely fail to activate #telomerase in the cell that is necessary to extend telomere length.

Speaking in September, 2013, Bill sums up the status and projections of his research and the response to Product B™.

“Using a program called Real time PCR we open a cell up after 24 hours of introducing a new activator and ask if any telomerase is being produced.  We have found 900 chemicals to date that stimulate telomerase production and have broken these down into 39 families of chemical structures.  Using these structures we have produced 100’s of new chemicals using a process called medicinal chemistry resulting in chemicals that are three to four times stronger than what we started with.  Right now we have chemicals that are 16 % what it takes to make a human cell immortal.

They are a little too toxic for human application and need to go through more safety studies but that is almost not important anymore because we have found natural compounds that are very potent, almost, but not quite as potent as our synthetics and I have a feeling it‘s just a few months before we find natural products that are more potent than any of our synthetics.

I have never seen so many anecdotal testimonies for any product ever.  I am a pharmaceutical  scientist by training. I believe in double blind placebo controlled studies. I believe that placebo         effects occur but I have just never seen this many testimonials before. I strongly believe  something is happening but I am not going to make any claims until the clinical studies are done.

There are going to be a lot of clinical studies done as we will investigate the testimonials to verify that they are real.”

Today Bill’s  10,200 square  foot laboratory in Reno, due to the stalled investment, has reduced it’s staff from 40 to 6 as work continues to find ever more potent safe telomerase activators to turn back the effects of aging. He says the science is fun and easy but the investment part is hard.

Having set aside his former $10,000 speaker’s fee he now eagerly speaks to any group of size that is interested in hearing the telomere story and the telomerase sub-plot that he is convinced will make “short telomere disease” a mere historical footnote as he envisions that we will go on to live active lives with 150 year wisdom in 24 year old bodies untouched by dementia.

Undaunted by the sag in financial support Bill Andrews has plans for at least the next $100 million budget that will include new generation telomere testing and scientific double blind studies confirming the wave of positive anecdotal reports.  Rumour has it that he is on the cusp of releasing a significantly improved generation of his Product B in the coming weeks. 

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Today Is The Day

Today is The Day

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In my email this morning I found these beautiful and poignant words with targeted relevance for me today. Not surprisingly so, because they come from “Veronica” via April Crawford (http://www.innerwhispers.org/) who consistently delivers these sparkling gems.  April calls herself a channeler, which confuses some people and frightens others.

Simply stated, as eternal and unlimited beings we are all connected to all existence and all knowledge at all times.  It’s just the density and distraction of the lead pancake -the distorted thoughts and expectations – that we drape over ourselves every morning,  courtesy of our enmeshed culture, family, media, society’s institutions etc., that distorts reality for us.  In fact, consider that you have been handed, and tangled in, a version of life and pseudo-reality that’s got just about everything upside down and wrong and then you will be much closer to the truth and also at the doorstep of wholeness and celebration like you have never known.

Channeling is much like the Nursery Rhymes’ “little girl with the little curl right in the middle of her forehead, who when she was good she was very good and when she was bad she was horrid.”  Get it right and it’s a vortex of inspiration, or not, and it can be a blight on your life’s path.  Channeling is nothing that needs to be vetted by your local priest, pastor, rabbi, imam or other guru.  These good and well-meaning souls are simply way-showers of the basics and challenged like the rest of us to participate in their own soul’s progress. They were never intended as pack mules for the spiritually languid and uncommitted who never aspire to more than poking with a stick at matters that connect the transformational present moment with infinity itself.

“Knowing”, “hearing”, from beyond is intuitive, something we all do already to a lesser or greater extent, and increasingly a required skill to be refined and used for the successful negotiating of the changing tides now incumbent on our world and individual daily lives. The final message comes, contrived or in truth, from the authenticity of your connection, transcending that part of us and that part of spiritual reality that has been beleaguered by the crust of life.  Its reliability and resonance is dependent on the degree of purity of our heart and our ability to recognize and hold the light within ourselves.  

So here’s “Veronica” (a collection of souls of a higher awareness) via April Crawford:

                                                  

                                                          TODAY IS THE DAY      

“Today, why not stand still in silence for a Moment and listen to the pulse of your soul?Today, why not speak your truth without fear of how it is received? 

Today, step forward and include your linear participation in your soul’s progress.     

Today, why not become more active in your soul intentions instead of settling for linear costumes?  

Today is the moment you truly reside in.  It is an opportunity to express your self with pure honesty.  A moment to color your perceptions with the clarity of the old soul you are becoming.

Often in the linear, one becomes lost in all the dramas, costumes, and props, while forgetting the true intentions of why they have arrived.

This moment needs joy.  This day will blossom with the intention of joy.  The awareness of all that is possible with clear thought should be continuously tucked within one’s heart.

The linear experience was meant to be fulfilling, while allowing the dense experience to fortify one’s spirit.

Glean as much knowledge and experience as you can.  Embrace the day, becoming one with the vivid experience of the current moment.

Today, be one with our soul.  Today, realize your potential and live it.  Do not allow others to rob you of the awareness of your potential.

It is your gift… your life, your opportunity to be more.

Yes it is difficult to embrace all of this.  Attempt every day to do so.  Do not give up.  Be the person you aspire to be.

Use all the experiences good and bad to achieve this.

Today is the day.”

VERONICA    

                                

                                                                                      

 

 

 

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Micro-Poetry, Black Swans and Steve Jobs: The Art of Imagining and Assembling New Worlds

There is only the dance 

until the swan dies.

                       ~  Bauke Kamstra
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This blog began with this poem and this exchange – http://bit.ly/10BlxQv – between Bauke – @Wyrde – and me.  Then my new Twitter friend from Australia, @TP_Hogan, chimed in - http://bit.ly/10BEW3P - and triggered  thoughts on Black Swans leading me to dust off and burnish some musings from my archives. 
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THE BLACK SWAN

The human opportunity is to turn flashes of insight into abiding light.

                                   ~  Huston Smith

Black Swan

Every now and then an unexpected and inexplicable event or product comes along that changes life as we have known it.  Labeled by some as a “Black Swan” such a random incident, occurring in history, science, finance, technology and the arts, transforms society.  

Totally surprised by the arrival of a Black Swan, society is substantially altered.  Afterward, when it cannot remember or conceive itself without the experience of that event or product, society finds a way of explaining and re-inventing itself around this necessary and inevitable arrival of a new defining pinion point.

The personal computer, the internet and the iPhone are Black Swan examples in technology.  It is interesting that Steve Jobs, known for his seeming ability to come up at will with repeated Black Swan creations such as the Macintosh computer, the iPod, iPad and iPhone, was not an inventor.  He was simply an assembler and integrator of existing technology and talent to produce society altering products.  Steve simply had a different and  Black Swan design for the standard issue of “Lego” pieces we all had on arrival.

Beyond his personal situation and challenges Steve Jobs was somehow able first to engage, then maintain, an inspired vision of the finished product as the active template which attracted, ordered and assembled diverse bits of talent and technology into the structure and profound impact of yet another Black Swan creation.

ARRIVAL OF THE BLACK SWAN

The oldest known reference to the term Black Swan comes from Juvenal, a Latin poet, writing 1900 years ago alluding to something that did not exist.  Juvenal’s expression became a common pejorative in 16th century London where all known swans were white.

In 1697 Dutch explorer Willem de Vlamingh discovered black swans in Western Australia, upending a social “certainty” and a tidy expression of that “truth”.  A little over a century later the clear thinking John Stuart Mill re-defined the Black Swan expression as an example of logical fallacy.  What once was an equation of certainty has become a maxim for the folly and unreliability of prematurely declaring the absolute certainty of a matter that is still in play in an expanding universe not unlike a sportscaster who would presume to announce the winning team after only the first inning of a baseball game.

In much the same way we find it easier to deify Christ than to enjoin his invitation to share with him a life of the miraculous, society  today prefers to endow Steve Jobs  with a status beyond the average person and still remains largely unaware that the Black Swan potential is about essence and opportunity, not individual talent.  It exists within any and every one of us who hears in a moment the angels sing then sets about unwaveringly to reorder their life and belief around that distant sound.   Such a resonant knowing if held and joined by like minds is inevitably manifested into a blessing for all, even if common understanding dismisses such a vision to be  as remote as the possibility of a black swan was in 16th century London.

Of course, upon fulfillment of this vision such a false perspective will simply be dismissed and forgotten and society will reorganize itself around the gift of this new way of life.

That is my inner knowing and expectation;  that’s why I am so optimistic.

In blackness where white swans last sing 

ever a new dance spreads its darkened wing   

                                                                               ~ Börje Melin
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What Black Swans do you already “know” about?

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